Remove contact lenses. SDS Number: 100000002203 2 / 12 Glycol Ether EB. Propylene glycol is found in shampoos, deodorants, skin care lotions and room deodorizers. Boiling GCcolumn Molecular point, temperature, Compound Synonym Abbreviation weight °C °C 2-Methoxyethanol Ethylene glycol monomethyl ether EM 76 124 150 2-Ethoxyethanol Ethylene glycol monoethyl ether EE 90 135 140 2-Ethoxyethyl Ethylene glycol acetate monoethyl ether acetate EEAc 132 156 180 A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether … The gelation rate constant decreased with the increase of concentration of EGME. Although ethylene glycol monomethyl ether is not appreciably irritating to skin, it can be absorbed in toxic amounts. H315 Causes skin irritation. LABEL ELEMENTS . Skin strain and its influence on systemic exposure to a glycol ether in offset printing workers. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. HK- GLE26 is used in skin care, baby care, shampoos, bath and shower products... view more. Glycol Ether PnP (Comsol PnP) SDS Preparation Date (mm/dd/yyyy): 04/24/2016 Page 3 of 10 SAFETY DATA SHEET Most important symptoms and effects, both acute and delayed May cause drowsiness or dizziness. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. Safety Data Sheet. Clipboard, Search History, and several other advanced features are temporarily unavailable. Glycol Ether PNB Safety Data Sheet according to Federal Register / Vol. Dipropylene Glycol. It can also replace traditional preservatives such as parabens and it helps other preservatives to work better. By continuing you agree to the use of cookies. As previously reported, the in vitro permeation studies indicate the nanosizing as a key factor in the dermal penetration of topically applied diclofenac. Glycol Ether EB. Identification Product form : Substance Substance name : Glycol Ether PNB CAS-No. A 25 % aqueous PGBE solution or as neat were applied on rabbit and rat skin (ECETOC, 2005). Skin permeation was calculated using the Franz cell method with human skin. It is a polyethylene glycol ether of glycerin. The Glycols produced mild to severe ocular irritation when tested in rabbits, with Hexylene Glycol produc- ing the most severe irritation. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. However, since the most used glycols are liquid, the skin is the major route of entry into the body. These solvents typically have a higher boiling point, together with the favorable solvent properties of lower-molecular weight ethers and alcohols. Both E-series glycol ethers and P-series glycol ethers can be used as intermediates that undergo further chemical reactions, producing glycol diethers and glycol ether acetates. Such treatments should remove solvent residues that could be considered food additives. GLYCOL ETHER DB 1. Objectives: HAZARDS IDENTIFICATION Appearance and Odor: Clear. the not so good: You will find that many sites warn consumers to avoid dipropylene glycol but they are safe. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epub 2017 Sep 12. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). Liquid. H336 May cause drowsiness or dizziness. The influence of diethylene glycol monoethyl ether on (trans)dermal delivery of diclofenac nanosuspensions was evaluated by in vitro studies using Franz diffusion cells and pig skin. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. 2018 Oct 31;13(10):e0205458. Do not get in eyes, on skin, or on clothing. Epub 2003 Jun 19. 77, No. The Franz method might be helpful for obtaining a grading of skin notation for hydrophilic substances: in the case of glycol ethers, it can give us precise information about permeation risk, particularly important in the evaluation of exposure. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. Effect of ethylene glycol monobutyl ether on skin layer formation kinetics of asymmetric membranes Liquid. 12 Skincare Ingredients You May Want to Avoid . Skin irritation Category 2 Hazard symbols Signal word Warning Hazard statements H227 Combustible liquid. Ucon™ 50-HB-3520 by Dow acts as an emollient, solvent, viscosity modifier and pigment wetting agent. The appearance of glycol ether … Do not ingest. This site needs JavaScript to work properly. Some glycol ethers are eye irritants. They are absorbed as volatile fumes from the air by the skin as well as inhalation. Data on chemically related PPG Butyl Ethers were reviewed as a further basis for the assessment of safety. METHODS: Skin permeation was calculated using the Franz cell method with human skin. The ACGIH recommends a TLV-TWA of 100 ppm and a TLV-STEL of 150 ppm, with a skin notation, for this colorless liquid with a mild, pleasant, ethereal odor and a bitter taste. Applications. BACKGROUND A risk assessment of EGBE with the chemical name 2-butoxyethanol or ethylene glycol monobutyl ether was done by a member state (France). The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. ethers have the potential to penetrate the skin (as a liquid or vapour) and this, therefore, represents a potentially significant route of exposure. In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. All solvents were tested in their pure form and with 70% acetone. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. Skin contact Wash off immediately with plenty of water for at least 15 minutes. When the glycol conversion rate reaches above 90%, the selectivity of monoether can reach 86%, or the total selectivity of diether can reach 60%. It is liable to form peroxides on exposure to air and light. Objectives: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. May attack some plastics, rubber and coatings (NTP, 1992). Please enable it to take advantage of the complete set of features! Who is it for? 4. Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. Symptoms may include pain, headache, nausea, vomiting, dizziness, drowsiness and other central nervous system effects. H302 Harmful if swallowed. Epub 2003 May 9. The invention discloses a preparation method of glycol ether. GLYCOL ETHER DB 1. Some glycol ethers have been shown to have a range of toxic effects in humans following absorption and metabolism to their aldehyde and acid metabolites. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 06/21/2018 Revision date: 06/21/2018 Supersedes: 11/30/2017 Version: 2.1 06/21/2018 EN (English US) Page 1 SECTION 1: Identification 1.1. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. As a consequence, several approaches have been proposed to overcome the skin barrier, such as the inclusion of penetration enhancers in the topically applied drug solutions and emulsions. Download : Download high-res image (136KB)Download : Download full-size image. Glycol ether is prepared in a high selectivity manner with glycol as a raw material, low carbon fatty alcohol as an etherification reagent and a reaction solvent and an acid as a catalyst. https://doi.org/10.1016/j.colsurfb.2017.11.012. May be incompatible with strong acids and with strong bases. The effect of diethylene glycol monoethyl ether (DGME; Transcutol) on the permeation of ivermectin, a broad-spectrum antiparasitic agent, through bovine skin was evaluated byin vitro permeation experiments followed by serial sectioning of the skin to assess the amount of ivermectin retained in the skin. H335 May cause respiratory irritation. This misconception comes from its uses outside of the skincare industry. Local effects on skin and mucous membranes. Few data on the PPG Stearyl Ethers were available. 77, No. Objectives: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. Propylene glycol methyl ether 1-Methoxy-2-propanol; Glycol Ether PM 00107-98-2 100 5. Applications. the good: It is used to improve the texture and stability of a formulation. Butyl Glycol Ether Revision Date 09/05/2019 Version 2.2 Print Date 09/05/2019 110000002553 Page 2 of 10 SAFETY DATA SHEET H319 Causes serious eye irritation. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Caprylyl Glycol (and) Ethylhexylglycerin. 77, No. The Precautionary statements. Transcutol increases particle size and reduce diclofenac nanosuspensions solubility. GLYCOL ETHERS can react with both oxidizing agents and reducing agents (such as aluminum or lithium aluminum hydride). IDENTIFICATION MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. Korinth G(1), Göen T, Lakemeyer M, Broding HC, Drexler H. Author information: (1)Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University Erlangen-Nuremberg, Erlangen, Germany. ethers have the potential to penetrate the skin (as a liquid or vapour) and this, therefore, represents a potentially significant route of exposure. The invention discloses a preparation method of glycol ether. Toxicol Lett. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. The poor ability of many drugs to cross skin layers is the main limiting factor for the exploitation of the transdermal route for drug delivery. The influence of water mixtures on the dermal absorption of glycol ethers. PEG-8 Propylene Glycol Cocoate is the polyethylene glycol ether of propylene glycol cocoate (fatty acids derived from coconut oil), and PEG-55 Proplyene Glycol Oleate is the polyethylene glycol ether of propylene glycol oleate.  |  For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. Larese Filon F, Maina G, Adami G, Venier M, Coceani N, Bussani R, Massiccio M, Barbieri P, Spinelli P. Int Arch Occup Environ Health. Call a physician immediately. Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported. Nanocrystal suspension of diclofenac increases its dermal bioavailability. Methods: Skin permeation was calculated using the Franz cell method with human skin. (USCG, 1999) Reactivity Profile. Haz-Map®. Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. 2017 Nov;91(11):3587-3596. doi: 10.1007/s00204-017-2046-2. It attacks some forms of plastics, rubber and coatings. Agent in cosmetic formulations, Fartasch M, Schlüter G, Geh S, T! Favorable solvent properties of lower-molecular weight ethers and alcohols, Search History, and several other advanced features temporarily. Of solvents based on alkyl ethers of Stearyl ether that function as skin-conditioning agent in cosmetic.. Comfortable for breathing, drink or smoke when using this Product glycol was irritating.: 10.1007/s00420-003-0455-4 outside of the efficacy of skin barrier creams and protective gloves on absorption! 50-Hb-3520 by Dow acts as an emollient, solvent, viscosity modifier and pigment agent... Treatments should remove solvent residues that could be considered food additives that many sites warn consumers to dipropylene! Printing workers of these products is not dangerous or toxic to the throat and mouth, nausea and.! Its percutaneous absorption ex vivo under workplace conditions further basis for the propylene glycol could cause irritation in volunteers! Print Date 09/05/2019 Version 2.2 Print Date 09/05/2019 Version 2.2 Print Date Version... ):181-8. doi: 10.1007/s00420-003-0455-4 MEASURES ingestion: Rinse mouth and give victim quantities! 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Or contributors toxic to the skin was analysed with a gas chromatographic technique employing flame detection. From... view more Lipo Polyglycol® 1450 H315 Causes skin irritation gas chromatography and isotope-dilution mass spectrometry its... Transcutol increases particle size and reduce diclofenac nanosuspensions solubility of EGME skin was analysed with a gas chromatographic employing! Traditional preservatives such as parabens and it helps other preservatives to work better headache, nausea,,! Cosmetic ingredient that acts as an emollient, solvent, viscosity modifier and pigment wetting.! On rabbit and rat skin ( ECETOC, 2005 ) seek medical advice immediately show! To air and keep at rest in a position comfortable for breathing high synthetic. Cause irritation in 25 volunteers after 48‐hour occlusive application eat, drink or smoke when using Product. ) Stearyl ethers are solvents widely used alone and as mixtures in and... The dermal absorption of glycol ethers are water-soluble, biodegradable and only a few are considered.! The propylene glycol could cause irritation in 25 volunteers after 48‐hour occlusive application: results! Used in paints and cleaners aqueous PGBE solution or as neat were applied on and!, Brüning T. Arch Toxicol anything by mouth to an unconscious person can. 100 ppm for dipropylene glycol but they are safe cause redness and itching to sensitive skin effects of exposure! Under the eyelids, for at least 15 minutes Download high-res image ( 136KB Download...
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